This Peptide Changes Everything

the next generation of metabolic Health

28%

Average body weight reduction. The highest ever recorded in a late-stage obesity trial

71 lbs

Average weight lost by users. More than any weight loss drug ever studied.

93%

Achieved normal liver fat levels at 48 weeks. Fatty liver disease reversed.

3x

Hormonal pathways targeted simultaneously: GLP-1, GIP, and Glucagon receptors
Excess weight is widely recognized by medical bodies as a chronic condition with a strong biological and hormonal component. Retatrutide works by supporting the correction of hormonal signals involved in appetite regulation, energy expenditure, and glucose control, as demonstrated in published clinical research.

clinical applications

Published clinical research on retatrutide spans multiple metabolic health areas.

Obesity & Weight Management

Blood Sugar & Glycemic Health

Liver Fat & Metabolic Health

Diabetic Kidney Disease

The most studied weight management compound ever

Retatrutide

Formula: C₂₂₁H₃₄₂N₄₆O₆₈
Specifications
Product Name: GLP-3 Quantity: 10/20/30mg (Lyophilized Powder) CAS #: Molecular Formula: C₂₂₃H₃₄₃F₃N₄₆O₇₀ Confirmed Molecular Weight (MS): 4728.48 Da Purity (HPLC): 99.6% Method of Analysis: HPLC-UV-MS
High Performance Liquid Chromatography (HPLC-UV) testing confirms: • Purity: 99.6% • Minimal secondary peak detection • Lot-specific Certificate of Analysis available
By completing your purchase, you confirm that you are a qualified professional conducting lawful scientific research. You agree that this compound is for research use only—not for human consumption or any non-research purpose. Reta 100 accepts no responsibility for misuse, mishandling, or improper application of this material.
Strictly for laboratory research, analytical testing, and scientific investigation. Research use only. Not for human consumption, therapeutic, or diagnostic use.

Targeting 3 Hormonal Pathways with 1 Peptide

Think of your metabolism like a lock with three keys. Most weight loss drugs only carry one. Retatrutide carries all three. Retatrutide simultaneously engages GLP-1, GIP, and glucagon receptors. The first in the world.

01

GLP-1 Receptor Activation

The mechanism includes stimulating insulin release, reducing glucagon secretion, suppressing appetite, and prolonging gastric emptying. GLP-1 receptors are expressed in multiple tissues—including the pancreas, brain, heart, kidneys, and gut—resulting in a broad spectrum of metabolic effects.
Suppresses brain hunger signals
Stabilizes blood sugar
Slow digestion keeps you full longer

02

GLP-1 Receptor Activation

This compound works synergistically with GLP-1 to boost insulin secretion and curb appetite. Additionally, GIP receptor activation affects bone metabolism and adipose tissue, reducing fat storage and supporting healthier lipid processing.
Amplify the body’s insulin response
Enhances how efficiently fat is stored and released
Deepens appettite-supressing effect of GLP-1

03

Glucagon Receptor Activation

Promotes energy expenditure, reduces lipogenesis, induces lipolysis, and reduces GI motility. Glucagon receptor action drives fat burning from the liver and adipose tissue, directly amplifying weight loss beyond what GLP-1 alone achieves.
Drives the liver to burn stored fat for fuel
Raises your metabolic rate
Keeps fat loss active between meals

METRIC

OZEMPIC

MOUNJARO

RETATRUTIDE

Receptors Targeted

1 (GLP-1)

2 (GLP-1, GIP)

3 (GLP-1, GIP, Glucagon)

Avg. Weight Loss (Max Dose)

15% (68 weeks)

22.5% (72 weeks)

28.7% (68 weeks, Phase 3)

Average Pounds Lost

34 lbs

48 lbs

71 lbs (Phase 3)

Fat Burning (Metabolism)

Appetite Only

Appetite + Insulin

Appetite + Insulin + Direct Fat Burn

Liver Fat Reduction

Moderate

Significant

93% Achieve Normal Liver Fat

Dosing Frequency

Once Weekly

Once Weekly

Once Weekly

Comparison data is drawn from the following published clinical trials: semaglutide (STEP-1), tirzepatide (SURMOUNT-1), and retatrutide (TRIUMPH-4, Phase 3, December 2025). Because these trials were conducted independently by different companies in distinct patient populations, the figures are not directly comparable without appropriate adjustment. Notably, individual outcomes varied considerably in all three studies.

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IMPORTANT LEGAL & MEDICAL DISCLAIMER — PLEASE READ
Retatrutide is an investigational compound not approved by the U.S. Food and Drug Administration (FDA) for the treatment, cure, or prevention of any disease or condition, including obesity or Type 2 diabetes. All products listed are for research and development purposes only and are strictly not for human consumption. Reta 100 is a wholesale chemical supplier—not a compounding pharmacy, compounding facility (as defined under 503A), or outsourcing facility (as defined under 503B). The statements on this website have not been evaluated by the FDA, and our products are not intended to diagnose, treat, cure, or prevent any disease. Information provided is based on clinical trial data and is for educational reference only.
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